Zingiber officinale Roscoe, commonly known as ginger belongs to the family Zingiberaceae is cultivated commercially in many parts of the world. It is used as a spice and flavoring agent and has many medicinal properties. However, only a limited amount of research exists to support their efficacy. The aim of the present study is to demonstrate the spasmolytic effect of ginger (Zingiber officinale) on chicken intestine preparation in vitro method. About 2 cm length ileum segment was cut, mounted in an organ bath containing Tyrode solution and continuously aerated and maintained at 37±0.5◦C. One end of the ileum was attached to aeration tube and the other end to an isotonic frontal writing lever attached to Sherrington recording drum with kymograph. Dose response curve of acetylcholine, histamine and serotonin were obtained and percentage contraction was recorded in presence and absence of Zingiber officinale extract (50,100 and 150μg/ml) and also compared with standard drugs like atropine, mepyramine and ondansetron. Effect of different concentration of Zingiber officinale extract was also recorded in acetylcholine induced contractions in the presence of nifedipine and BaCl2 and KCl induced contraction. Inhibitory effect of ZOE on various spasmogens acetylcholine, histamine and serotonin were dose dependent and completely reversible. Zingiber officinale extract might have exerted its antidiarrhoeal effect by antagonism on the acetylcholine, histamine and serotonin receptors. It may have caused blockade of muscarinic, histaminic or/and serotonin receptors or directly Ca2+channels. Spasmolytic effects of the extract of Zingiber officinale could be exploited for other therapeutic uses of the plant.
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